ABSTRACT
Objective:To evaluate the diagnostic efficiency of hypersensitivity quantitative fecal immunochemical test (hs-qFIT) in colorectal cancer (CRC) and advanced adenoma.Methods:From July to December 2020, consecutive patients aged 50 to 75 years who underwent colonoscopy in Qilu Hospital of Shandong University, and had the Asia-Pacific colorectal screening score of medium or high risk were enrolled. All patients were requested to complete two hs-qFIT before colonoscopy. The diagnostic efficacy of hs-qFIT for CRC and advanced adenoma were assessed. Receiver operating characteristic curve of hs-qFIT in CRC diagnosis was drawn and the area under the curve (AUC) was calculated.Results:A total of 811 patients including 20 (2.5%) cases of CRC, 47 (5.8%) cases of advanced adenoma, 206 (25.4%) cases of non-advanced adenoma, 219 (27.0%) cases of non-adenomatous polyp, 76 (9.4%) cases of other colorectal lesions and 243 (30.0%) cases of non-colorectal lesions were involved. When the fecal hemoglobin cut-off values were 10, 30, 50, 75 and 100 ng/mL, the positive rates of hs-qFIT detection were 17.9% (145/811), 10.9% (88/811), 8.3% (67/811), 7.4% (60/811) and 5.8% (47/811), respectively. When the cut-off value of fecal hemoglobin decreased from 100 ng/mL to 10 ng/mL, the sensitivity of hs-qFIT for CRC diagnosis increased from 90.0% to 100.0%, and the specificity decreased from 96.3% to 84.2%; and the sensitivity of hs-qFIT for the diagnosis of advanced adenoma increased from 19.1% to 66.0%, and the specificity decreased from 95.0% to 85.1%. The AUC of hs-qFIT for the diagnosis of CRC and advanced adenoma were 0.981 (95% confidence interval ( CI) 0.970 to 0.992) and 0.846 (95% CI 0.807 to 0.886), respectively. When the optimal cut-off values were taken, the sensitivity and specificity were 100.0% and 91.2% for the diagnosis of CRC, and 66.0% and 85.3% for the diagnosis of advanced adenoma, respectively. Conclusion:Hs-qFIT can help the early screening of CRC and advanced adenoma.
ABSTRACT
Objective To analyze the epidemiological and temporal-spatial distribution characteristics of hemorrhagic fever with renal syndrome (HFRS) in Shandong province during 2010-2016 and provide references for developing prevention and control measures.Methods Based on the data of Infectious Disease Reporting Information System in China,the incidence and temporal-spatial distribution of HFRS in Shandong from 2010 to 2016 were analyzed by spatial autocorrelation and space-time scan statistics.Results A total of 9 114 HFRS cases were reported in Shandong during this period.The cases were mainly distributed in age group 30-70 years,and the male to female ratio of the cases was 2.63 ∶ 1.Most cases were farmers.The higher incidence rate was reported in southeastern Shandong,while the lower incidence rate was reported in northwestern Shandong.Among the epidemic periods,the highest incidence rate was 1.87/100 000 in 2013.The results of spatial autocorrelation and space-time scanning indicated that the high-high clusters of HFRS were concentrated in southeastern Shandong and then spread to central Shandong.The cluster mainly occurred from the end of 2011 to the first half of 2015.Both the incidence rate and the cluster decreased in 2016.Conclusions The epidemic and cluster of HFRS still existed in Shandong from 2010 to 2016.The key areas for the prevention and control of HFRS were in southeastern and central Shandong.
ABSTRACT
Objective To analyze the epidemiological and temporal-spatial distribution characteristics of hemorrhagic fever with renal syndrome (HFRS) in Shandong province during 2010-2016 and provide references for developing prevention and control measures.Methods Based on the data of Infectious Disease Reporting Information System in China,the incidence and temporal-spatial distribution of HFRS in Shandong from 2010 to 2016 were analyzed by spatial autocorrelation and space-time scan statistics.Results A total of 9 114 HFRS cases were reported in Shandong during this period.The cases were mainly distributed in age group 30-70 years,and the male to female ratio of the cases was 2.63 ∶ 1.Most cases were farmers.The higher incidence rate was reported in southeastern Shandong,while the lower incidence rate was reported in northwestern Shandong.Among the epidemic periods,the highest incidence rate was 1.87/100 000 in 2013.The results of spatial autocorrelation and space-time scanning indicated that the high-high clusters of HFRS were concentrated in southeastern Shandong and then spread to central Shandong.The cluster mainly occurred from the end of 2011 to the first half of 2015.Both the incidence rate and the cluster decreased in 2016.Conclusions The epidemic and cluster of HFRS still existed in Shandong from 2010 to 2016.The key areas for the prevention and control of HFRS were in southeastern and central Shandong.